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FT671

Cat. No. M10817
FT671  Structure
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Biological Activity

FT671 is a potent, non-covalent, selective USP7 inhibitor,IC50 The value is 52 nM, bound to the USP7 catalytic domain Kd The value is 65 nM.

Chemical Information
Molecular Weight 533.48
Formula C24H23F4N7O3
CAS Number 1959551-26-8
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yiwei Wang, et al. Cell Res. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

[2] Andrew P Turnbull, et al. Nature. Molecular basis of USP7 inhibition by selective small-molecule inhibitors

[3] Fabricio L Tulini, et al. J Dairy Res. Screening for antimicrobial and proteolytic activities of lactic acid bacteria isolated from cow, buffalo and goat milk and cheeses marketed in the southeast region of Brazil

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  Catalog
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