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Fluorofenidone

Cat. No. M20838

All AbMole products are for research use only, cannot be used for human consumption.

Fluorofenidone Structure
Synonym:

AKF-PD

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Quality Control & Documentation
Biological Activity

Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway.

Chemical Information
Molecular Weight 203.21
Formula C12H10FNO
CAS Number 848353-85-5
Solubility (25°C) DMSO 41 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Cheng Song, et al. Shock. FLUOROFENIDONE ATTENUATES PULMONARY INFLAMMATION AND FIBROSIS BY INHIBITING THE IL-11/MEK/ERK SIGNALING PATHWAY

[2] Xiaohua Liao, et al. Oxid Med Cell Longev. Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage

[3] Feiya Jiang, et al. Med Sci Monit. Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

[4] Hua Zhuang, et al. Arq Bras Oftalmol. Fluorofenidone inhibits epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification

[5] Cheng Song, et al. J Cell Mol Med. Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway

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Keywords: Fluorofenidone, AKF-PD supplier, inhibitors, activators

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