Certificate of Analysis
| Product Name: | Fluorofenidone |
| Catalog Number: | M20838 |
| CAS Number: | 848353-85-5 |
Physical and Chemical Properties
| Formula: | C12H10FNO |
| Molecular Weight: | 203.21 |
| Solubility: | DMSO 41 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |