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Farletuzumab

Cat. No. M25269
Farletuzumab Structure
Synonym:

MORAb-003

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Quality Control & Documentation
Biological Activity

Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a therapeutic humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer.

Chemical Information
CAS Number 896723-44-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Toshio Shimizu, et al. Clin Cancer Res. First-in-Human Phase 1 Study of MORAb-202, an Antibody-Drυg Conjugate Comprising Farletuzumab Linked to Eribulin Mesylate, in Patients with Folate Receptor-α-Positive Advanced Solid Tumors

[2] Xin Cheng, et al. Mol Cancer Ther. MORAb-202, an Antibody-Drυg Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity

[3] Seiya Sato, et al. Onco Targets Ther. Profile of farletuzumab and its potential in the treatment of solid tumors

[4] Anish Thomas, et al. Lung Cancer. Farletuzumab in lung cancer

[5] Whitney A Spannuth, et al. Expert Opin Biol Ther. Farletuzumab in epithelial ovarian carcinoma

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Keywords: Farletuzumab, MORAb-003 supplier, Antibiotic, inhibitors, activators


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