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Cat. No. M11456
Evixapodlin Structure

PD-1/PD-L1-IN 7; GS-4224

Size Price Availability Quantity
5mg USD 340  USD340 In stock
10mg USD 540  USD540 In stock
25mg USD 1020  USD1020 In stock
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Quality Control & Documentation
Biological Activity

Evixapodlin (PD-1/ PD-L1-in 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. Evixapodlin has anti-cancer and anti-virus properties.

Chemical Information
Molecular Weight 691.61
Formula C34H36Cl2N8O4
CAS Number 2374856-75-2
Form Solid
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Evixapodlin, PD-1/PD-L1-IN 7; GS-4224 supplier, PD-1/PD-L1, inhibitors, activators

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