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Escin Ie

Cat. No. M40125
Escin Ie Structure
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Biological Activity

Escin Ie is a derivative of Aescine in Aesculi Semen extract.

Chemical Information
Molecular Weight 969.12
Formula C49H76O19
CAS Number 1613506-26-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Giulia Vanti et al. J Control Release. Escinosome thermosensitive gel optimizes efficacy of CAI-CORM in a rat model of rheumatoid arthritis

[2] Brandon P Kitchens et al. Wounds. A Literature Review of Pharmacological Agents to Improve Venous Leg Ulcer Healing

[3] Hung-Chen Lee et al. Am J Transl Res. Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathway

[4] Ramsia Sreij et al. Mol Pharm. Interaction of the Saponin Aescin with Ibuprofen in DMPC Model Membranes

[5] C R Sirtori. Pharmacol Res. Aescin: pharmacology, pharmacokinetics and therapeutic profile

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