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Erigeroside

Cat. No. M40076
Erigeroside Structure
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Biological Activity

Erigeroside is as a derivatives of -glucose extracted from Satureja khuzistanica Jamzad. Erigeroside has good ability of anti-oxidation and scavenging oxidation free radical.

Chemical Information
Molecular Weight 274.22
Formula C11H14O8
CAS Number 59219-76-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhifeng Zhang et al. J Pharm Biomed Anal. Simultaneous determination of five main active constituents of Erigeron multiradiatus by HPLC-DAD-MS

[2] Mohsen Tafazzoli et al. Spectrochim Acta A Mol Biomol Spectrosc. Dynamic stereochemistry of erigeroside by measurement of 1H-1H and 13C-1H coupling constants

[3] Y Ding et al. J Tongji Med Univ. The effect of Erigeron breviscapus on proliferation of pulmonary artery smooth muscle cells in hypoxic porcines

[4] Y Hashidoko. Biosci Biotechnol Biochem. Pyromeconic acid and its glucosidic derivatives from leaves of Erigeron annuus, and the siderophile activity of pyromeconic acid

[5] C Q Hu et al. Yao Xue Xue Bao. [Total synthesis of erigeroside and preliminary observation on experimental microcirculatory disturbances]

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