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Epothilone A

Cat. No. M20888
Epothilone A Structure
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Biological Activity

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.

Chemical Information
Molecular Weight 493.66
Formula C26H39NO6S
CAS Number 152044-53-6
Solubility (25°C) DMSO 99 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Marina Herwerth, et al. Brain. A new form of axonal pathology in a spinal model of neuromyelitis optica

[2] Ramesh Prasad Pandey, et al. Biotechnol Appl Biochem. UPLC-PDA coupled HR-TOF ESI/MS2 -based identification of derivatives produced by whole-cell biotransformation of epothilone A using Nocardia sp. CS692 and a cytochrome P450 overexpressing strain

[3] Prakash Parajuli, et al. Glycoconj J. Enzymatic synthesis of lactosylated and sialylated derivatives of epothilone A

[4] Prakash Parajuli, et al. AMB Express. Enzymatic synthesis of epothilone A glycosides

[5] Karl-Heinz Altmann. Mini Rev Med Chem. Epothilone B and its analogs - a new family of anticancer agents

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