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Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion-carrier that can be used for cuproptosis studies. By Affymetrix microarray analysis, Elesclomol significantly induced the expression of heat shock stress response genes and metallothionein genes in Hs294T cells treated at 100 nM for 6 h. Ramos Burkitt's lymphoma B cells were treated with Elesclomol (100 nM) for 1 h and 6 h, respectively, and the Hsp70 RNA level was rapidly increased by 4.8 times and 160 times, which was consistent with the intracellular ROS content. After 0.5 h and 6 h Elesclomol treatment, ROS content increased by 20% and 385%, respectively. Antioxidant N-acetylcysteine (NAC) and Tiron pretreatment could inhibit the induction of Hsp70. HSB2 cells treated with 200 nM Elesclomol for 18 h could induce oxidative stress and increase the apoptotic cells in early stage and late stage by 3.7 times and 11 times, respectively. The above effects could be completely inhibited by NAC, but had no effect on normal cells.
| Molecular Weight | 400.52 |
| Formula | C19H20N4O2S2 |
| CAS Number | 488832-69-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cuproptosis Products |
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| Cu(II)-Elesclomol
Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. |
| DL-Penicillamine
DL-Penicillamine is a copper chelating agent. DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. |
| UM4118
UM4118 is a copper ionophore which can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research. |
| Ammonium tetrathiomolybdate
Ammonium tetrathiomolybdate is a copper chelator and also is a class of sulfide donor. Ammonium tetrathiomolybdate has neuroprotection effects. Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. |
| 2,2'-Bipyridine
2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
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