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Elacridar hydrochloride

Cat. No. M6706
Elacridar hydrochloride Structure
Synonym:

GF120918A

Size Price Availability Quantity
10mg USD 162  USD180 In stock
50mg USD 468  USD520 In stock
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Quality Control
Biological Activity

Elacridar hydrochloride is a p-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 600.1
Formula C34H33N3O5.HCl
CAS Number 143851-98-3
Purity >98%
Solubility DMSO 6 mg/mL (May need ultrasonic)
Storage at -20°C
References

5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron.
Seynaeve, et al. Anticancer Drugs. 1991;2: 343. PMID: 1665723.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Elacridar hydrochloride, GF120918A supplier, P-gp, inhibitors

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