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Eflapegrastim

Cat. No. M24638

All AbMole products are for research use only, cannot be used for human consumption.

Eflapegrastim Structure

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Quality Control & Documentation
Biological Activity

Eflapegrastim is a humanized IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia.

Chemical Information
CAS Number 1384099-30-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] No authors listed. Med Lett Drugs Ther. Eflapegrastim (Rolvedon) for prevention of chemotherapy-induced febrile neutropenia

[2] No authors listed. Am J Health Syst Pharm. Eflapegrastim-xnst

[3] Douglas W Blayney, et al. Cancer Treat Rev. Chemotherapy-induced neutropenia and emerging agents for prevention and treatment: A review

[4] John A Barrett, et al. Exp Hematol. Eflapegrastim's enhancement of efficacy compared with pegfilgrastim in neutropenic rats supports potential for same-day dosing

[5] Lee S Schwartzberg, et al. Oncologist. Eflapegrastim, a Long-Acting Granulocyte-Colony Stimulating Factor for the Management of Chemotherapy-Induced Neutropenia: Results of a Phase III Trial

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Keywords: Eflapegrastim supplier, CSF-1R (c-Fms), inhibitors, activators

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