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Drotaverine is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, and it is also an L-type voltage-dependent calcium channel (L-VDCC) blocker, Drotaverine blocks the degradation of 3',5'-cyclic adenosine monophosphate. Inhibition of PDE4 leads to elevated levels of cAMP, leading to smooth muscle relaxation.
Drotaverin also acts as a cytostatic compound for several human tumor cell lines and nonmalignant mouse fibroblasts, and EC50 values as low as 3.0 μM were observed in SRB assays for HT-29 human colorectal carcinoma cells.
| Molecular Weight | 411.49 |
| Formula | C24H29NO5 |
| CAS Number | 54088-62-9 |
| Solubility (25°C) | DMSO (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Ajay Shyam Kanbur, et al. Indian J Urol. Drotaverine-induced priapism
[4] Vyom Aggarwal. Indian Pediatr. Drotaverine for Recurrent Abdominal Pain in Children
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