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DPP

Cat. No. M42103
DPP Structure
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Biological Activity

DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand.

Chemical Information
Molecular Weight 926.7
Formula C36H40Cl2N2O10Pt
CAS Number 2668267-47-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Snehasish Nag et al. Future Virol. DPP-4 Inhibitors as a savior for COVID-19 patients with diabetes

[2] Emi Kawakita et al. Cancers (Basel). CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology

[3] Daiji Kawanami et al. Antioxidants (Basel). Renoprotective Effects of DPP-4 Inhibitors

[4] Wei Wei Bao et al. Front Chem. Diketopyrrolopyrrole (DPP)-Based Materials and Its Applications: A Review

[5] Bo Ahrén. Front Endocrinol (Lausanne). DPP-4 Inhibition and the Path to Clinical Proof

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Keywords: DPP supplier, JAK, inhibitors, activators


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