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Cat. No. M21352
Dovramilast Structure


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Biological Activity

Dovramilast (CC-11050) is a phosphodiesterase 4 (PDE4) inhibitor with oral activity that reduces the inflammatory response and improves Isoniazid-mediated clearance of bacteria from the lung. Dovramilast is used as an adjuvant in tuberculosis studies.

Chemical Information
Molecular Weight 472.55
Formula C24H28N2O6S
CAS Number 340019-69-4
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Dovramilast, CC-11050 supplier, PDE, inhibitors, activators

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