Free shipping on all orders over $ 500

DOV 216,303

Cat. No. M7767

All AbMole products are for research use only, cannot be used for human consumption.

DOV 216,303 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

DOV 216,303 is a potent triple inhibitor of 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine reuptake with IC50 values of 20, 14, and 78 nM, respectively.

Chemical Information
Molecular Weight 264.58
Formula C11H11Cl2N · HCl
CAS Number 86215-36-3
Solubility (25°C) DMSO ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tak-Ho Chu, et al. The triple monoamine re-uptake inhibitor DOV 216,303 promotes functional recovery after spinal cord contusion injury in mice

[2] Gunnar Srensen, et al. Addiction-related effects of DOV 216,303 and cocaine: A comparative study in the mouse

[3] J Prins, et al. The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats

[4] Bernard Beer, et al. DOV 216,303, a "triple" reuptake inhibitor: safety, tolerability, and pharmacokinetic profile

Related 5-HT Receptor Products
PF-03382792

PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain.

Tegaserod

Tegaserod is an orally active serotonin receptor 4 (5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation.

cis-Urocanic acid

cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is also an immune modulator that induces immunosuppression.

5-HT2B antagonist-1

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM.

AS19 

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: DOV 216,303 supplier, 5-HT Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.