Free shipping on all orders over $ 500

Dolasetron Mesylate

Cat. No. M20521

All AbMole products are for research use only, cannot be used for human consumption.

Dolasetron Mesylate Structure
Synonym:

Anzemet hydrate

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

Dolasetron Mesylate is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Chemical Information
Molecular Weight 420.48
Formula C20H24N2O6S
CAS Number 115956-13-3
Solubility (25°C) DMSO 84 mg/mL
Water 28 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. Dolasetron

[2] Stephanie Weibel, et al. Cochrane Database Syst Rev. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

[3] No authors listed. Anesth Analg. Dolasetron for preventing postanesthetic shivering: Retraction

[4] J A Balfour, et al. Drugs. Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery

Related 5-HT Receptor Products
PF-03382792

PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain.

Tegaserod

Tegaserod is an orally active serotonin receptor 4 (5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation.

cis-Urocanic acid

cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is also an immune modulator that induces immunosuppression.

5-HT2B antagonist-1

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM.

AS19 

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Dolasetron Mesylate, Anzemet hydrate supplier, 5-HT Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.