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Cat. No. M13545
DL-Buthionine-(S,R)-sulfoximine Structure

Buthionine sulfoximine; BSO

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100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

Chemical Information
Molecular Weight 222.31
CAS Number 5072-26-4
Solubility (25°C) Water 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Gabriela Diaz de Barboza, et al. World J Gastroenterol. Oxidative stress, antioxidants and intestinal calcium absorption

[2] Mark F Belmonte, et al. Plant Cell Rep. Applications of DL-buthionine-[S,R]-sulfoximine deplete cellular glutathione and improve white spruce (Picea glauca) somatic embryo development

[3] A Marchionatti, et al. Comp Biochem Physiol C Toxicol Pharmacol. DL-Buthionine-S,R-sulfoximine affects intestinal alkaline phosphatase activity

[4] E P Kable, et al. Cancer Res. Sensitivity of human melanoma cells to L-dopa and DL-buthionine (S,R)-sulfoximine

[5] M F Chen, et al. Cancer Lett. Effect of DL-buthionine-S,R-sulfoximine on 1,2-dimethyl-hydrazine-induced colonic tumors in rats

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Keywords: DL-Buthionine-(S,R)-sulfoximine, Buthionine sulfoximine; BSO supplier, Ferroptosis, inhibitors, activators

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