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Dickkopf-related protein 1(DKK-1) secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.
Recombinant Human Dickkopf-related Protein 1 expressed the target gene encoding Thr32-His266 with a 8His tag at the N-terminus.
Immobilized Human DKK-1-His at 2μg/ml (100 μl/well) can bind Anti-Human DKK-1 mAb, the ED50 of Anti-Human DKK-1 mAb is 5.57 ng/ml.
Accession: O94907
Endotoxin < 0.01 EU/µg
Apparent Molecular Weight: 35-50 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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