Free shipping on all orders over $ 500

Recombinant Human DKK-1(Mammalian,N-8His)

Cat. No. M11533
Recombinant Human DKK-1(Mammalian,N-8His) Structure

Dickkopf-related protein 1;Dickkopf-1;Dkk-1

Size Price Availability Quantity
10ug USD 300  USD300 In stock
50ug USD 800  USD800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >95% , Endotoxin <0.01 EU/ug
  • COA
  • MSDS
Biological Activity

Purity: > 95% as determined by reduced SDS-PAGE.
Endotoxin :LAL determination: less than 0.001 ng/ug (0.01 EU/ug).
Storage: Freeze-dried protein should be stored at < -20°C, but at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.

Biological activity: DickkopF-related protein 1(DKK-1) is a member of the DickkopF family. The protein secreted by DKK1 has two cysteine-rich regions separated by junction regions. It antagonizes typical Wnt signaling by inhibiting lRP5/6 interaction with Wnt and forming ternary complexes with transmembrane protein KREMEN that promote lRP5/6 internalization. In adults, Dkks has been associated with bone formation and bone disease, cancer and Alzheimer's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
CAS Number
Purity >95% , Endotoxin <0.01 EU/ug
Solubility It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Storage < -20°C

[1] Marcin Czepiel, et al. Arthritis Rheumatol. Down-Regulation of Dkk-1 in Platelets of Patients With Axial Spondyloarthritis

[2] Yuan-Hada He, et al. Arch Gynecol Obstet. Detection of DKK-1 gene methylation in exfoliated cells of cervical squamous cell carcinoma and its relationship with high risk HPV infection

[3] John Henderson, et al. Exp Dermatol. Wnt antagonist DKK-1 levels in systemic sclerosis are lower in skin but not in blood and are regulated by microRNA33a-3p

[4] Jaewoong Jang, et al. Sci Rep. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

[5] Libo Liang, et al. Tumour Biol. Preliminary mechanism on the methylation modification of Dkk-1 and Dkk-3 in hepatocellular carcinoma

Related Cytokines Products
Recombinant Mouse IL-10 (CHO)

Recombinant Mouse IL-10 (CHO) belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI.

Recombinant Human PCSK9 (Mammalian,C-6His)

Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692(Val474Ile,Gly670Glu) is expressed with a 6His tag at the C-terminus. Accession #: Q8NBP7.

Recombinant Mouse RANKL (E.coli)

Recombinant Mouse TNF Ligand Superfamily Member 11 is produced by our E.coli expression system and the target gene encoding Lys158-Asp316 is expressed. Accession #: O35235.

Recombinant Human EpCAM/Trop1 (Expi293, His)

Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1/4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain.

Recombinant Human Wnt3a (Mammalian)

Recombinant human protein WnT-3A is produced by the mammalian expression system, and the target gene encoding Ser19-Lys352 is expressed at the N-terminal by fusion design. Accession # : P56704.

Abmole Inhibitor Catalog

Keywords: Recombinant Human DKK-1(Mammalian,N-8His), Dickkopf-related protein 1;Dickkopf-1;Dkk-1 supplier, Cytokines, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.