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Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines. Target: 5-HT Receptors Dihydroergotamine is not as effective as sumatriptan or phenothiazines as a single agent for treatment of acute migraine headache; however, when administered with an antiemetic, dihydroergotamine appears to be as effective as opiates, ketorolac, or valproate. Given its nonnarcotic properties, parenteral dihydroergotamine combined with an antiemetic should be considered as effective initial therapy in clinical practice. The introduction of the intranasal formulation of DHE provides both pharmacologic and patient-convenience advantages for use in migraine therapy [2, 3].
| Molecular Weight | 679.78 |
| CAS Number | 6190-39-2 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
[4] R B Lipton. Headache. Ergotamine tartrate and dihydroergotamine mesylate: safety profiles
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