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Diflomotecan

Cat. No. M29358

All AbMole products are for research use only, cannot be used for human consumption.

Diflomotecan Structure
Synonym:

BN 80915

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Quality Control & Documentation
Biological Activity

Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds.

Chemical Information
Molecular Weight 398.36
Formula C21H16F2N2O4
CAS Number 220997-97-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Víctor Mangas-Sanjuan, et al. J Pharmacol Exp Ther. Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules

[2] Judith R Kroep, et al. Expert Opin Investig Drugs. Diflomotecan, a promising homocamptothecin for cancer therapy

[3] Alex Sparreboom, et al. Clin Pharmacol Ther. Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

[4] Neil Osheroff. IDrugs. Diflomotecan. Ipsen

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  Catalog
Abmole Inhibitor Catalog




Keywords: Diflomotecan, BN 80915 supplier, Topoisomerase, inhibitors, activators

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