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DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.
| Molecular Weight | 585.8 |
| Formula | C31H47N5O4S |
| CAS Number | 2245887-38-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 12.5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | Powder -20°C |
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