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Deoxycholic acid sodium salt

Cat. No. M11152
Deoxycholic acid sodium salt Structure

Sodium deoxycholate

Size Price Availability Quantity
100mg USD 60  USD60 In stock
500mg USD 83  USD83 In stock
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Quality Control & Documentation
Biological Activity

Deoxycholic acid sodium salt activates the G protein-coupled bile acid receptor TGR5.

Chemical Information
Molecular Weight 416.58
Formula C24H41NaO4
CAS Number 302-95-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Xintong Zhang, et al. Acta Pharm Sin B. The influence of the gut microbiota on the bioavailability of oral drugs

[2] Maimuna Majimbi, et al. PLoS One. Sodium alginate microencapsulation improves the short-term oral bioavailability of cannabidiol when administered with deoxycholic acid

[3] Kiyoaki Ito, et al. Hepatology. Dual Agonist of Farnesoid X Receptor and Takeda G Protein-Coupled Receptor 5 Inhibits Hepatitis B Virus Infection In Vitro and In Vivo

[4] Aliya F Gulamhusein, et al. Nat Rev Gastroenterol Hepatol. Primary biliary cholangitis: pathogenesis and therapeutic opportunities

[5] Tao Wang, et al. Food Sci Nutr. Why is glycocholic acid sodium salt better than deoxycholic acid sodium salt for the preparation of mixed micelle injections?

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Keywords: Deoxycholic acid sodium salt, Sodium deoxycholate supplier, GPCR19/TGR5, inhibitors, activators

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