Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL
Molecular Weight | 293.36 |
Formula | C19H19NO2 |
CAS Number | 7630-74-2 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | 2-8°C, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] J M Sa, et al. J Org Chem. Dehydroaporphines. Dichlorocarbene addition to dehydronuciferine
Related AChR/AChE Products |
---|
Catestatin
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. |
α-Conotoxin MII
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. |
COG 133 TFA
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. |
α-Bungarotoxin
α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). |
G-Protein antagonist peptide
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.