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Dehydronuciferine

Cat. No. M10623
Dehydronuciferine Structure
Size Price Availability Quantity
5mg USD 360  USD360 In stock
10mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL

Chemical Information
Molecular Weight 293.36
Formula C19H19NO2
CAS Number 7630-74-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao-Liang Zhao, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from leaves of Nelumbo nucifera]

[2] J M Sa, et al. J Org Chem. Dehydroaporphines. Dichlorocarbene addition to dehydronuciferine

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Keywords: Dehydronuciferine supplier, AChR/AChE, inhibitors, activators


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