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Dehydroepiandrosterone

Cat. No. M9061
Dehydroepiandrosterone Structure
Synonym:

DHEA; Prasterone; Dehydroisoandrosterone

Size Price Availability Quantity
100mg USD 55  USD55 In stock
250mg USD 110  USD110 In stock
500mg USD 175  USD175 In stock
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Quality Control & Documentation
Biological Activity

Dehydroepiandrosterone is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells (Caco2 cell line).

In vivo, DHEA in the diet (0.45 % w/w) of male B6 mice (groups of five mice) treated for 8 weeks led to significant decreases in body temperature compared with mice fed the control AIN-76A diet.

Chemical Information
Molecular Weight 288.42
Formula C19H28O2
CAS Number 53-43-0
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] McNelis JC, et al. Am J Physiol Endocrinol Metab. Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake.

[2] Anagnostopoulou V, et al. Endocrinology. Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors.

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Keywords: Dehydroepiandrosterone, DHEA; Prasterone; Dehydroisoandrosterone supplier, Animal Modeling, inhibitors, activators


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