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Decoglurant

Cat. No. M9646
Decoglurant Structure
Synonym:

RG-1578; RO4995819

Size Price Availability Quantity
5mg USD 448  USD448 In stock
10mg USD 746  USD746 In stock
25mg USD 1344  USD1344 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Decoglurant (also known as RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 447.34
Formula C21H11F6N5
CAS Number 911115-16-7
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

[1] Samuel T Wilkinson, et al. Drv g Discov Today. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems

[2] H Javelot. Ann Pharm Fr. Psychopharmacology of anxiety and depression: Historical aspects, current treatments and perspectives

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