Free shipping on all orders over $ 500

DC661

Cat. No. M20648

All AbMole products are for research use only, cannot be used for human consumption.

DC661 Structure
Size Price Availability Quantity
2mg USD 120  USD120 In stock
5mg USD 220  USD220 In stock
10mg USD 380  USD380 In stock
25mg USD 760  USD760 In stock
50mg USD 1180  USD1180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).

Chemical Information
Molecular Weight 552.58
Formula C31H39Cl2N5
CAS Number 1872387-43-3
Solubility (25°C) DMSO 62 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pengfei Yuan, et al. J Neurochem. Poly (ADP-ribose) polymerase 1-mediated defective mitophagy contributes to painful diabetic neuropathy in the db/db model

[2] Vito W Rebecca, et al. Cancer Discov. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

[3] Vaibhav Jain, et al. Cancer Discov. Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

[4] Gaurav Sharma, et al. JCI Insight. PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

Related Autophagy Products
Vacuolin-1

Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation.

CA77.1 

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics.

KAN0438757 

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.

Metofenazate

Metofenazate is a selective calmodulin inhibitor.

Patulin

Patulin (Terinin) is a mycotoxin produced by a variety of fungi, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.

  Catalog
Abmole Inhibitor Catalog




Keywords: DC661 supplier, Autophagy, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.