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Cat. No. M20648
DC661 Structure
Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 380  USD380 In stock
25mg USD 760  USD760 In stock
50mg USD 1180  USD1180 In stock
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Quality Control & Documentation
Biological Activity

DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).

Chemical Information
Molecular Weight 552.58
Formula C31H39Cl2N5
CAS Number 1872387-43-3
Solubility (25°C) DMSO 62 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jianjun Xu, et al. Cancer Cell Int. High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma

[2] Pengfei Yuan, et al. J Neurochem. Poly (ADP-ribose) polymerase 1-mediated defective mitophagy contributes to painful diabetic neuropathy in the db/db model

[3] Vito W Rebecca, et al. Cancer Discov. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

[4] Vaibhav Jain, et al. Cancer Discov. Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

[5] Gaurav Sharma, et al. JCI Insight. PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

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Keywords: DC661 supplier, Autophagy, inhibitors, activators

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