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dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1.
| Molecular Weight | 699.18 |
| Formula | C34H31ClN8O5S |
| CAS Number | 1883863-52-2 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | 2-8°C, protect from light |
| Related PROTAC Products |
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