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Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).
| Molecular Weight | 710.52 |
| Formula | C21H22F2N8O10P2S2 |
| CAS Number | 2553413-86-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Naiim Ali, et al. Abdom Radiol (NY). Kissing artifact
[2] Liam du Preez, et al. Abdom Radiol (NY). Shofar sign
[4] Robert D'Agostino. Abdom Radiol (NY). Cloverleaf duodenum
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c-di-AMP disodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. |
| SN-011
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. |
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| STING-IN-6
STING-IN-6 is a potent STING inhibitor with a pIC50 of 8.9. |
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