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D-(+)-Fucose

Cat. No. M19035
D-(+)-Fucose Structure
Size Price Availability Quantity
5mg USD 43  USD43 In stock
10mg USD 60  USD60 In stock
50mg USD 88  USD88 In stock
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Biological Activity

D-(+)-Fucose

Chemical Information
CAS Number 3615-37-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kouta Takeda, et al. Curr Opin Chem Biol. Fungal PQQ-dependent dehydrogenases and their potential in biocatalysis

[2] Sergio Alatorre-Santamara, et al. Appl Biochem Biotechnol. Synthesis of Fucose-Containing Disaccharides by Glycosylhydrolases from Various Origins

[3] Benedetta Bertolotti, et al. Org Biomol Chem. Polyvalent C-glycomimetics based on l-fucose or d-mannose as potent DC-SIGN antagonists

[4] Raluca-Ioana Stefan-van Staden, et al. Analyst. Determination of L- and D-fucose using amperometric electrodes based on diamond paste

[5] H M Flowers. Adv Carbohydr Chem Biochem. Chemistry and biochemistry of D- and L-fucose

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