Free shipping on all orders over $ 500

CZC-8004

Cat. No. M9548
CZC-8004 Structure
Synonym:

Dianilinopyrimidine-01

Size Price Availability Quantity
5mg USD 108  USD108 In stock
10mg USD 183  USD183 In stock
50mg USD 760  USD760 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 309.34
Formula C17H16FN5
CAS Number 916603-07-1
Purity >98.5%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
References

[1] Fiona M Deane, et al. ACS Omega. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification

[2] Marcus Bantscheff, et al. Nat Biotechnol. Quantitative Chemical Proteomics Reveals Mechanisms of Action of Clinical ABL Kinase Inhibitors

Related Src-bcr-Abl Products
1NM-PP1

1NM-PP1 is a cell-permeable and potent Src family kinases inhibitor with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively.

TL02-59

TL02-59 is a selective, orally active Src-family kinase Fgr inhibitor with IC50 of 0.03 nM, it also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively.

Flumatinib mesylate

Flumatinib mesylate is a selective inhibitor of BCR-ABL/PDGFR/c-Kit with IC50s of 1.2 nM, 307.6 nM and 2662 nM, respectively.

Asciminib

Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL, with a Kd value of 0.5-0.8 nM.

TG-100572 hydrochloride

TG-100572 hydrochloride is a potent and selective multi-targeted VEGFR2/Src kinase inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: CZC-8004, Dianilinopyrimidine-01 supplier, Src-bcr-Abl, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.