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Cysteine Protease inhibitor

Cat. No. M14305
Cysteine Protease inhibitor Structure
Size Price Availability
5mg USD 330  USD330 1-2 Weeks
10mg USD 480  USD480 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Cysteine Protease inhibitor is an inhibitor of cysteine protease. IC50 & Target: Cysteine Protease

Chemical Information
Molecular Weight 302.33
CAS Number 921625-62-9
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dbora do Carmo Linhares, et al. Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and Characterization

[2] Thị Lam Thi, et al. Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro

[3] Nana Wei, et al. A Tick Cysteine Protease Inhibitor RHcyst-1 Exhibits Antitumor Potential

[4] Lin Chen, et al. Cysteine protease inhibitor of Schistosoma japonicum - A parasite-derived negative immunoregulatory factor

[5] Mika K Lindvall. Molecular modeling in cysteine protease inhibitor design

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Keywords: Cysteine Protease inhibitor supplier, Cathepsin, inhibitors, activators

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