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Cystamine dihydrochloride is a transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
| Molecular Weight | 225.2 |
| Formula | C4H12N2S2.2HCl |
| CAS Number | 56-17-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 22.52 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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