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Cycloleucine

Cat. No. M10378
Cycloleucine Structure
Synonym:

1-Aminocyclopentanecarboxylic acid

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 100  USD100 In stock
1g USD 135  USD135 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine (4-40 mM) 3 hours blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. 

In vivo, Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats. Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 129.16
Formula C6H11NO2
CAS Number 52-52-8
Purity >98%
Solubility Water 50 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Augusto P I Gargiulo, et al. Neuropsychobiology. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats

[2] S Amor, et al. Br J Exp Pathol. The effect of cycloleucine on SFV A7(74) infection in mice

[3] W F Hood, et al. Eur J Pharmacol. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor

[4] K Dimock, et al. Biochemistry. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA

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Keywords: Cycloleucine, 1-Aminocyclopentanecarboxylic acid supplier, GluR, inhibitors

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