Free shipping on all orders over $ 500


Cat. No. M10378
Cycloleucine Structure

1-Aminocyclopentanecarboxylic acid

Size Price Availability Quantity
100mg USD 45  USD50 In stock
500mg USD 90  USD100 In stock
1g USD 121.5  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine (4-40 mM) 3 hours blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. 

In vivo, Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats. Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 129.16
Formula C6H11NO2
CAS Number 52-52-8
Purity >98%
Solubility Water 50 mg/mL
Storage -20°C, protect from light, sealed

Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats
Augusto P I Gargiulo, et al. Neuropsychobiology. 2020;79(3):191-197. PMID: 31927553.

The effect of cycloleucine on SFV A7(74) infection in mice
S Amor, et al. Br J Exp Pathol. 1987 Apr;68(2):225-35. PMID: 3034321.

1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor
W F Hood, et al. Eur J Pharmacol. 1989 Feb 28;161(2-3):281-2. PMID: 2542048.

Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA
K Dimock, et al. Biochemistry. 1978 Aug 22;17(17):3627-32. PMID: 210799.

Related GluR Products
L-Methionine sulfoximine

L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase (GS) activity, used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines.


Decoglurant (also known as RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors.


Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate.


CX546 is a selective positive AMPA glutamate receptor modulator.

(+)-MK 801 Maleate

(+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

Abmole Inhibitor Catalog 2017

Keywords: Cycloleucine, 1-Aminocyclopentanecarboxylic acid supplier, GluR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.