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Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I.
| Molecular Weight | 462.05 |
| Formula | C19H18CuN4O2S2 |
| CAS Number | 1224195-72-5 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cuproptosis Products |
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| DL-Penicillamine
DL-Penicillamine is a copper chelating agent. DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. |
| UM4118
UM4118 is a copper ionophore which can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research. |
| Ammonium tetrathiomolybdate
Ammonium tetrathiomolybdate is a copper chelator and also is a class of sulfide donor. Ammonium tetrathiomolybdate has neuroprotection effects. Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. |
| 2,2'-Bipyridine
2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
| Trientine-2HCl
Trientine-2HCl is a chelating agent used in the study of Wilson's disease by binding and scavenging copper from the body.Trientine-2HCl is also used as a chelating agent for copper in hepatocyte degeneration, as a stabilizer for epoxy resins, and as an ampholyte for isoelectric focusing. |
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