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CP 55940

Cat. No. M45339

All AbMole products are for research use only, cannot be used for human consumption.

CP 55940 Structure
Synonym:

CP-55,940

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Quality Control & Documentation
Biological Activity

CP 55940 is a variant full agonist of the CB1 receptor that exhibits high and approximately equal affinity for central and peripheral cannabinoid receptors, with Ki's of 0.6 - 5.0 and 0.7-2.6 nM for CB1 and CB2, respectively, and EC50 values of 0.2 and 0.3 nM for CB1 and CB2, respectively.In addition, when acting on GRP55, the EC50 value is 5 nM.

Chemical Information
Molecular Weight 376.57
Formula C24H40O3
CAS Number 83003-12-7
Form Solid
Solubility (25°C) DMF 30 mg/mL
DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Avdesh Avdesh, et al. Psychopharmacology (Berl). Pharmacological effects of cannabinoids on the reference and working memory functions in mice

[2] S J Ward, et al. Behav Pharmacol. The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940)

[3] Suresh Sundram, et al. Naunyn Schmiedebergs Arch Pharmacol. Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens

[4] Christy S Norwood, et al. Eur J Pharmacol. Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats

[5] B Dean, et al. Neuroscience. Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use

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Keywords: CP 55940, CP-55,940 supplier, Cannabinoid, inhibitors, activators

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