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Coralyne chloride 

Cat. No. M30034

All AbMole products are for research use only, cannot be used for human consumption.

Coralyne chloride  Structure

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Quality Control & Documentation
Biological Activity

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes.

Chemical Information
Molecular Weight 399.87
Formula C22H22ClNO4
CAS Number 38989-38-7
Form Solid
Solubility (25°C) Water 4 mg/mL (ultrasonic and warming and heat to 60°C)
DMSO 1.82 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 4°C, dry, sealed
References

[1] Zeqing Jiao, et al. J Chem Phys. Sequence-specific binding behavior of coralyne toward triplex DNA: An ultrafast time-resolved fluorescence spectroscopy study

[2] Jiawen Han, et al. Biosens Bioelectron. Recent advancements in coralyne (COR)-based biosensors: Basic principles, various strategies and future perspectives

[3] Birija Sankar Patro, et al. J Photochem Photobiol B. Mechanism of coralyne-mediated DNA photo-nicking process

[4] Szu-Ying Hung, et al. Biosens Bioelectron. A polyadenosine-coralyne complex as a novel fluorescent probe for the sensitive and selective detection of heparin in plasma

[5] D Makhey, et al. Bioorg Med Chem. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

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  Catalog
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Keywords: Coralyne chloride  supplier, Topoisomerase, inhibitors, activators

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