All AbMole products are for research use only, cannot be used for human consumption.
For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.
C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2). Likewise, C108 pretreatment prior to xenografting greatly reduces BT-474 tumor-initiating frequency (from 1/175 to 1/1103 by limiting dilution xenograft assays) in mice in vivo. G3BP2 is reported to bind and stabilize SART3 mRNA, thereby indirectly regulating the core pluripotency transcription factors Oct-4 and Nanog critically involved in ESC self-renewal and breast tumor initiation.
| Molecular Weight | 270.28 |
| Formula | C15H14N2O3 |
| CAS Number | 15533-09-2 |
| Solubility (25°C) | DMSO: 2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Nisha Gupta, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation
| Related Products |
|---|
| KY-556
KY-556 (N-556) is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases. |
| 2,6-dichlorophenolindophenol
2,6-dichlorophenolindophenol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| L-Lactic acid lithium
L-Lactic acid lithium is a lithium salt of L-Lactic acid with certain bioconductive properties. L-Lactic acid can be used as a precursor for the production of bioplastic polymer polylactic acid. |
| Lithium lactate
Lithium lactate (Lithium 2-hydroxypropanoate) is a kind of biological materials or organic compounds that are widely used in life science research. Lithium lactate is a biochemical reagent which can be used for the determination of lactic acid. |
| Lithium stearate
Lithium stearate (Stearic acid lithium) is a compound that forms vesicles in reaction with silver nitrate, thereby changing the reaction kinetics of the nucleation and self-assembly process of silver stearate. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
