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Clidinium Bromide

Cat. No. M20926
Clidinium Bromide Structure
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Quality Control & Documentation
Biological Activity

Clidinium Bromide is an anticholinergic drug.

Chemical Information
Molecular Weight 432.35
Formula C22H26BrNO3
CAS Number 3485-62-9
Solubility (25°C) DMSO 86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Siripa Puasripun, et al. J Neurogastroenterol Motil. Efficacy and Safety of Clidinium/Chlordiazepoxide as an Add-on Therapy in Functional Dyspepsia: A Randomized, Controlled, Trial

[2] Christine K Nessim, et al. J AOAC Int. Novel Stability-Indicating Chemometric-Assisted Spectrophotometric Methods for the Determination of Chlordiazepoxide and Clidinium Bromide in the Presence of Clidinium Bromide's Alkali-Induced Degradation Product

[3] Safwan Ashour, et al. J Pharm (Cairo). Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography

[4] S E Richardson, et al. Emerg Med J. Accidental acute clidinium toxicity

[5] M I Toral, et al. Int J Pharm. Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

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