Cinnamaldehyde is a naturally occurring flavonoid found in the bark of Cinnamomum cinnamomi and other Cinnamomum species such as camphor and cinnamon, and can act through a variety of signaling pathways, including PPARs, AMPK, PI3K/IRS-1, RBP4-GLUT4, ERK/JNK/p38MAPK, TRPA1-ghrelin, and the Nrf2 pathways.Cinnamaldehyde also has the potential to modulate the activities of PTP1B and α-amylase with antifungal activity and antioxidant activity.
Molecular Weight | 132.16 |
Formula | C9H8O |
CAS Number | 104-55-2 |
Form | Liquid |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Amanda A Doyle, et al. A review of cinnamaldehyde and its derivatives as antibacterial agents
[4] Sheikh Shreaz, et al. Cinnamaldehyde and its derivatives, a novel class of antifungal agents
[5] Bang-Jiao Chen, et al. Cinnamaldehyde Analogues as Potential Therapeutic Agents
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