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CGP52421

Cat. No. M3800
CGP52421 Structure
Size Price Availability
5mg USD 90  USD90 Out of stock
10mg USD 150  USD150 Out of stock
50mg USD 450  USD450 Out of stock
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Quality Control & Documentation
Biological Activity

CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).

Chemical Information
Molecular Weight 600.66
Formula C36H32N4O5
CAS Number 179237-49-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wang Y, et al. J Clin Pharmacol. Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus.

[2] Illmer T, et al. J Pharmacol Toxicol Methods. A highly sensitive method for the detection of PKC412 (CGP41251) and its metabolites by high-performance liquid chromatography.

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  Catalog
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Keywords: CGP52421 supplier, FLT3, inhibitors, activators


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