Free shipping on all orders over $ 500

CD532 

Cat. No. M28750

All AbMole products are for research use only, cannot be used for human consumption.

CD532  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer.

Chemical Information
Molecular Weight 522.52
Formula C26H25F3N8O
CAS Number 1639009-81-6
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hua Ye, et al. Int J Gen Med. Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance

[2] Zahra Musavizadeh, et al. Biomolecules. Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

[3] James A H Gilburt, et al. Angew Chem Int Ed Engl. Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

[4] Richard Bayliss, et al. Biochem Soc Trans. A moving target: structure and disorder in pursuit of Myc inhibitors

[5] Mark W Richards, et al. Proc Natl Acad Sci U S A. Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Related Aurora Kinase Products
Phthalazinone pyrazole 

Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM.
Aurora Kinases-IN-4

Aurora Kinases-IN-4 is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM).
Derrone

Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity.
CD532 hydrochloride 

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.
Aurora kinase inhibitor-2 

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.
  Catalog
Abmole Inhibitor Catalog




Keywords: CD532  supplier, Aurora Kinase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.