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Aurora Kinases-IN-4 is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM).
Molecular Weight | 468.55 |
Formula | C26H28N8O |
CAS Number | 2877011-84-0 |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Hoi Tang Ma et al. Mutat Res. Aurora kinases and DNA damage response
[3] Anqun Tang et al. Oncotarget. Aurora kinases: novel therapy targets in cancers
[4] Min Yan et al. Med Res Rev. Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy
[5] Victor M Bolanos-Garcia. Int J Biochem Cell Biol. Aurora kinases
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Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity. |
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AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. |
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