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CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein.
| Molecular Weight | 992.42 |
| Formula | C50H50ClN7O13 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage | -20°C, dry, sealed |
| Related PROTAC Products |
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| Setidegrasib
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| PROTAC HK2 Degrader-1
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| ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
| MS4322
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