Certificate of Analysis
| Product Name: | CCT367766 formic |
| Catalog Number: | M31074 |
Physical and Chemical Properties
| Formula: | C50H50ClN7O13 |
| Molecular Weight: | 992.42 |
| Form: | Solid |
| Solubility: | DMSO ≥ 200 mg/mL |
| Storage: | -20°C, dry, sealed |
Analytical Data
| QC Standard: | ≥98.0% |
Product Information
| Description: | CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |