Free shipping on all orders over $ 500

CCR2 antagonist 5 

Cat. No. M27990

All AbMole products are for research use only, cannot be used for human consumption.

CCR2 antagonist 5  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease.

Chemical Information
Molecular Weight 482.52
Formula C22H25F3N4O3S
CAS Number 1228650-83-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tobias Puengel, et al. Int J Mol Sci. Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis

[2] Ruaa Al-Qazazi, et al. Am J Respir Crit Care Med. Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

[3] Ronghui Lin, et al. J Labelled Comp Radiopharm. Synthesis of deuterium-labeled CCR2 antagonist JNJ-26131300, [4-(1H-indol- 3-yl)-piperidin-1-yl]-{1-[3-(3,4,5-trifluoro-phenyl)-acryloyl]-piperidin-4-yl}-acetic acid

[4] Aditya Ambade, et al. Hepatology. Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice

Related CCR Products
C-021 dihydrochloride

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively.

C-021

C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively.

AZD-5672 

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM).
MLN3126 

MLN3126 is an orally active and potent CCR9 antagonist.
AZD2423 

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator.
  Catalog
Abmole Inhibitor Catalog




Keywords: CCR2 antagonist 5  supplier, CCR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.