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CB-25

Cat. No. M41791
CB-25 Structure
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Biological Activity

CB-25 is a ligand of CB1 cannabinoid receptors, acting as a partial agonist.

Chemical Information
Molecular Weight 403.6
Formula C25H41NO3
CAS Number 869376-63-6
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Steffen U Thorsen et al. J Immunol. Maternal and Cord Blood 25-Hydroxyvitamin D3 Are Associated with Increased Cord Blood and Naive and Activated Regulatory T Cells: The Barwon Infant Study

[2] Youn Ho Sheen et al. Pediatr Pulmonol. Interaction between 25-hydroxyvitamin D and variants at 17q12-21 on respiratory infections

[3] A P Jones et al. Clin Exp Allergy. 25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life

[4] Anderson P Jones et al. Pediatrics. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy

[5] J Shoji et al. J Antibiot (Tokyo). Isolation of CB-25-I, an antifungal antibiotic, from Serratia plymuthica

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