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Cabiralizumab

Cat. No. M24735

All AbMole products are for research use only, cannot be used for human consumption.

Cabiralizumab Structure
Synonym:

FPA 008; Anti-Human CSF1R Recombinant Antibody

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Quality Control & Documentation
Biological Activity

Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab can combine with Nivolumab for lung cancer research.

Chemical Information
CAS Number 1613144-80-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Corey C Foster, et al. Clin Cancer Res. Phase I Study of Stereotactic Body Radiotherapy plus Nivolumab and Urelumab or Cabiralizumab in Advanced Solid Tumors

[2] Lu Yin, et al. Am J Dermatopathol. Papillary Dermal Elastolysis Secondary to Combination Nivolumab and Cabiralizumab Therapy: Histiocytes and Dermal Mucin as Clues to the Diagnosis

[3] Long Yuan, et al. Bioanalysis. A bridging immunogenicity assay for anti-cabiralizumab antibodies: overcoming the low assay cut point and drυg tolerance challenges

[4] John A Gonzales, et al. Am J Ophthalmol Case Rep. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis

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Keywords: Cabiralizumab, FPA 008; Anti-Human CSF1R Recombinant Antibody supplier, CSF-1R (c-Fms), inhibitors, activators

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