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Bucladesine calcium

Cat. No. M9782

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Bucladesine calcium Structure
Synonym:

Dibutyryl cAMP calcium salt

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Quality Control & Documentation
Biological Activity

Bucladesine calcium is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium is also a phosphodiesterase (PDE) inhibitor.

Chemical Information
Molecular Weight 978.84
Formula C36H48CaN10O16P2
CAS Number 938448-87-4
Solubility (25°C) Water ≥ 80 mg/mL
DMSO ≥ 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Forouz Salehi, et al. Fundam Clin Pharmacol. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain

[2] Chris Rundfeldt, et al. Arch Dermatol Res. The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation

[3] Mohammad Sharifzadeh, et al. Eur J Pharmacol. Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats

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Keywords: Bucladesine calcium, Dibutyryl cAMP calcium salt supplier, PKA, inhibitors, activators

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