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Bucladesine calcium

Cat. No. M9782
Bucladesine calcium Structure
Synonym:

Dibutyryl cAMP calcium salt

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100mg USD 90  USD100 4-7 Days
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Quality Control
  • Current batch:
  • Purity >96%
  • COA
  • MSDS
Biological Activity

Bucladesine calcium is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium is also a phosphodiesterase (PDE) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 978.84
Formula C36H48CaN10O16P2
CAS Number 938448-87-4
Purity >96%
Solubility Water ≥ 80 mg/mL
DMSO ≥ 80 mg/mL
Storage at -20°C
References

Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain
Forouz Salehi, et al. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419. PMID: 28267871.

The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
Chris Rundfeldt, et al. Arch Dermatol Res. 2012 May;304(4):313-7. PMID: 22302126.

Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats
Mohammad Sharifzadeh, et al. Eur J Pharmacol. 2007 May 21;562(3):212-20. PMID: 17379207.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bucladesine calcium, Dibutyryl cAMP calcium salt supplier, PKA, inhibitors

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