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8-Bromo-cAMP

Cat. No. M1593
8-Bromo-cAMP Structure
Synonym:

8-Br-cAMP sodium salt

Size Price Availability Quantity
10mM*1mL in DMSO USD 49.5  USD55 In stock
5mg USD 45  USD50 In stock
10mg USD 58.5  USD65 In stock
25mg USD 117  USD130 In stock
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Quality Control
Biological Activity

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 430.08
Formula C10H10BrN5NaO6P
CAS Number 76939-46-3
Purity 100.00%
Solubility DMSO ≥ 35 mg/mL (Need warming)
Storage at -20°C
References

A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.
Wang Y, et al. Stem Cell Rev Rep. 2011 Jun;7(2):331-41. PMID: 21120637.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 8-Bromo-cAMP, 8-Br-cAMP sodium salt supplier, PKA, inhibitors

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