Free shipping on all orders over $ 500


Cat. No. M1593
8-Bromo-cAMP Structure

8-Br-cAMP sodium salt

Size Price Availability Quantity
10mM*1mL in DMSO USD 49.5  USD55 In stock
5mg USD 45  USD50 In stock
10mg USD 58.5  USD65 In stock
25mg USD 117  USD130 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 430.08
Formula C10H10BrN5NaO6P
CAS Number 76939-46-3
Purity 100.00%
Solubility DMSO ≥ 35 mg/mL (Need warming)
Storage at -20°C

A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.
Wang Y, et al. Stem Cell Rev Rep. 2011 Jun;7(2):331-41. PMID: 21120637.

Related PKA Products
Bucladesine calcium

Bucladesine calcium is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP.


CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50 values of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively.


H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.

Bucladesine Sodium Salt

Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner.

H-89 Dihydrochloride

H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM.

Abmole Inhibitor Catalog 2017

Keywords: 8-Bromo-cAMP, 8-Br-cAMP sodium salt supplier, PKA, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.